There is increasing evidence that hypoxia plays an important role in cancer dormancy and cancer metabolism, increasing stemness activity and bringing about cancer initiation and progression. This condition may influence the production of hypoxia inducible factor (HIF) …
Hypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer drug target. Many recent studies have provided convincing evidences of strong correlation between …
2004229· Hypoxia-inducible factor (HIF-1) is an oxygen-dependent transcriptional activator, which plays crucial roles in the angiogenesis of tumors and mammalian …
Besides lung, postnatal human epidermis is the only epithelium in direct contact with atmospheric oxygen. Skin epidermal oxygenation occurs mostly through atmospheric …
The growing l.ist of pharmacological inhibitors of HIF-1 and their varied targets mirrors the complex molecular mechanisms controlling HIF-1. In this chapter, we summarize recent …
20171221· Hypoxia is a physiological characteristic of a wide range of diseases from cancer to infection. Cellular hypoxia is sensed by oxygen-sensitive hydrolase enzymes, …
2008114· Background Hypoxia-inducible factor 1 alpha (HIF-1α) is involved in processes promoting carcinogenesis of many tumors. However, its role in the …
Patients with negatively or weakly HIF-1alpha-expressing tumors had a survival rate of 80%, whereas the survival decreased to only 33.6% in case of moderate or strong …
Colorectal cancer (CRC) is the third most common cancer worldwide and despite the abundance of molecular pathways and markers continually being reported, the mortality …
2020612· ng. Thus, this meta-analysis was carried out to assess the connection between HIF-1α gene polymorphisms (rs, rs, and rs) and lung cancer risk. PubMed, Embase, Cochrane Library, and Google Scholar were systematically searched up to November 1, 2018. The study quality was quantified by the …
201761· Subsequently, we found that IDF-11774 inhibited the expression of the HIF-1 target genes VEGF and EPO, which are involved in angiogenesis, but not of the gene encoding HIF-1α itself ().Therefore ...
uptake and distribution. Hence, conserved oxygen-de-pendent responsive pathways are expressed in almost ... but not HIF-1α promotes growth of renal carcinoma cell (Kondo et al., 2002; Maranchie ...
2014117· This study investigates the expression of hypoxia-inducible factor-l alpha (HIF-1α) and carbonic anhydrase IX (CAIX) in nasopharyngeal carcinoma (NPC) tissues and their correlation with clinicopathological features and prognosis in NPC patients. The expression of HIF-1α and CAIX proteins was detected by immunohistochemical staining …
2020624· Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide and is characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1 alpha (HIF-1α) is a major regulator of cellular response to changes in oxygen concentration, supporting the adaptation of tumor cells to hypoxia in an oxygen …
2020618· ，HIF-1α pVHL HIF-1α 。 ， PHD HIF-1α 。 HIF-1α HIF-1α ，， HIF-1β HIF-1 。
2001221· Abstract Background: Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that regulates gene expression in critical pathways involved in tumor growth and metastases. In this report, we investigated whether the level of HIF-1α is increased during carcinogenesis ...
2007130· Validation of HIF-1α immunostaining: (a) Immunohistochemical staining of HIF-1α in formalin-fixed, paraffin-embedded CAL51 cells cultured in normoxia (20% O 2) or under hypoxia (1–2% O 2) during 4 hr. (b) Immunohistochemical staining of HIF-1α in sections of mouse xenograft tumours fixed after different times of incubation in normoxic …
La subunidad alfa del factor 1 inducible por hipoxia (HIF1A) es una proteína codificada en humanos por el gen HIF1A.[1] [2] Se han descrito dos variantes transcripcionales que codifican diferentes isoformas de la proteína.Estructura HIF1 es un heterodímero con un dominio hélice-bucle-hélice básico [4] compuesto por HIF1A, referida como subunidad …
200811· For pRCC there was no correlation between HIF-1alpha mRNA and tumor stage, nuclear grade, age, tumor size or gender. HIF-1alpha mRNA expression was inversely related to HIF-1alpha protein levels ...
2008215· Richard DE, Berra E, Gothie E, Roux D, Pouyssegur J . p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity ...
2020612· ng. Thus, this meta-analysis was carried out to assess the connection between HIF-1α gene polymorphisms (rs, rs, and rs) and lung cancer risk. PubMed, Embase, Cochrane Library, and Google Scholar were systematically searched up to November 1, 2018. The study quality was quantified by the …
2021621· Of note, no difference in the growth of HIF-1α (Del)-tumors and HIF-1α (FL)-tumors was observed in immunocompromised NOD scid gamma (NSG) mice lacking mature B, T, and NK cells (Fig. 2E ...
uptake and distribution. Hence, conserved oxygen-de-pendent responsive pathways are expressed in almost ... but not HIF-1α promotes growth of renal carcinoma cell (Kondo et al., 2002; Maranchie ...
2018119· Nuclear translocation of c-MYC, in turn, enhanced the expression of the c-MYC-dependent genes HIF-1α, Cdc25a, ELK-1, and JUN. The oncogenes HIF-1α and ELK-1 promote cancer progression by ...
2015129· In clear cell renal cell carcinoma (CCRCC) VHL-defective RCC4 and RCC10 cells, binding of HIF-1α/2α to the reverse HRE (rHRE) on the HIF1A promoter, leads to H3K9 methylation, H3K4 de ...
2014322· Hypoxia is a common feature of many solid tumors, including hepatocellular carcinoma (HCC). Hypoxia can promote tumor progression and induce radiation and chemotherapy resistance. As one of the major mediators of hypoxic response, hypoxia inducible factor-1 (HIF-1) has been shown to activate hypoxia-responsive genes, …
2007130· Validation of HIF-1α immunostaining: (a) Immunohistochemical staining of HIF-1α in formalin-fixed, paraffin-embedded CAL51 cells cultured in normoxia (20% O 2) or under hypoxia (1–2% O 2) during 4 hr. (b) Immunohistochemical staining of HIF-1α in sections of mouse xenograft tumours fixed after different times of incubation in normoxic …
La subunidad alfa del factor 1 inducible por hipoxia (HIF1A) es una proteína codificada en humanos por el gen HIF1A.[1] [2] Se han descrito dos variantes transcripcionales que codifican diferentes isoformas de la proteína.Estructura HIF1 es un heterodímero con un dominio hélice-bucle-hélice básico [4] compuesto por HIF1A, referida como subunidad …
2001221· Abstract Background: Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that regulates gene expression in critical pathways involved in tumor growth and metastases. In this report, we investigated whether the level of HIF-1α is increased during carcinogenesis ...
2008215· Richard DE, Berra E, Gothie E, Roux D, Pouyssegur J . p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity ...
20091130· Intratumoral hypoxia is a major mechanism underlying the increased levels of HIF-1α and HIF-2α in cancer and stromal cells. For example, the median P O 2 level measured in breast cancers was 10 ...
2021621· Of note, no difference in the growth of HIF-1α (Del)-tumors and HIF-1α (FL)-tumors was observed in immunocompromised NOD scid gamma (NSG) mice lacking mature B, T, and NK cells (Fig. 2E ...
2018119· Nuclear translocation of c-MYC, in turn, enhanced the expression of the c-MYC-dependent genes HIF-1α, Cdc25a, ELK-1, and JUN. The oncogenes HIF-1α and ELK-1 promote cancer progression by ...
202073· The stringent expression of the hypoxia inducible factor-1α (HIF-1α) is critical to a variety of pathophysiological conditions. We reveal that, in normoxia, enzymatic action of cystathionine β-synthase (CBS) produces H 2 S, which persulfidates prolyl hydroxylase 2 (PHD2) at residues Cys 21 and Cys 33 (zinc finger motif), augmenting …
201569· It is well recognized that hypoxia-inducible factor 1 alpha (HIF-1α) is involved in cancer metastasis, chemotherapy and poor prognosis. We previously found that deferoxamine, a hypoxia-mimetic agent, induces epithelial-mesenchymal transition (EMT) in colorectal cancer. Therefore, here we explored a new molecular mechanism for HIF-1α …
Marina D Hendrickson, Robert O Poyton Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO, USA Abstract: Hypoxia-inducible factor-1 (HIF-1) is responsible for cellular adaptations to hypoxia. While oxygen (O 2) negatively regulates its stability, many other factors affect HIF-1 stability and activity, …
2014322· Hypoxia is a common feature of many solid tumors, including hepatocellular carcinoma (HCC). Hypoxia can promote tumor progression and induce radiation and chemotherapy resistance. As one of the major mediators of hypoxic response, hypoxia inducible factor-1 (HIF-1) has been shown to activate hypoxia-responsive genes, …
2013111· Angiogenesis, which plays an important role in tumor growth and progression of breast cancer, is regulated by a balance between pro- and anti-angiogenic factors. Expression of vascular endothelial growth factor (VEGF) is up-regulated during hypoxia by hypoxia-inducible factor-1α (HIF-1α). It is known that there is an interaction …
20131226· High expression of HIF-1α in HCC is also significantly associated with poor DFS and OS rate in HCC patients. Our data suggest that HIF-1α is an unfavorable prognostic factor in HCC patients, which is in agreement with other in …
